Understanding how the STING pathway is regulated in the body
Regulation of the STING pathway under sterile conditions
This study is looking at how the STING pathway in our immune system is controlled to help prevent it from overreacting and causing autoimmune diseases, and the findings could lead to new treatments for people with inflammatory conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project ID | NIH-10671724 on NIH RePORTER |
What this research studies
This research investigates the regulation of the STING pathway, which plays a crucial role in the immune response to infections. By exploring how this pathway is kept in a resting state, the study aims to uncover mechanisms that prevent harmful immune responses that can lead to autoimmune diseases. The research involves examining cellular processes and interactions, particularly focusing on the endoplasmic reticulum and its role in signaling. Patients may benefit from insights that could lead to new treatments for inflammatory diseases linked to STING pathway activation.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals suffering from autoimmune diseases such as rheumatoid arthritis or systemic lupus erythematosus.
Not a fit: Patients with non-autoimmune conditions or those not affected by inflammatory diseases may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for managing autoimmune diseases and inflammatory conditions.
How similar studies have performed: Previous research has shown promising results in understanding immune signaling pathways, suggesting that this approach could yield valuable insights.
Where this research is happening
Los Angeles, United States
- University of California Los Angeles — Los Angeles, United States (Active)
Researchers
- Principal investigator: Srikanth, Sonal — University of California Los Angeles
- Study coordinator: Srikanth, Sonal
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.