Understanding how the immunoproteasome affects metabolic disorders
Mechanisms of immunoproteasome-mediated metabolic disorders
This study is looking at how a special protein complex called the immunoproteasome affects metabolism and energy balance in the body, especially in the liver, to see if it can help with obesity and metabolic problems, and it’s being tested using modified mice to find new ways to treat these issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Minnesota NIH-funded |
| Lab location | 1 site (Minneapolis, United States) |
| Project ID | NIH-10398812 on NIH RePORTER |
What this research studies
This research investigates the role of the immunoproteasome, a specialized protein complex that becomes more active during inflammation, in regulating metabolism and energy balance in the body. By studying how the immunoproteasome digests specific proteins, the researchers aim to uncover its impact on liver function and overall energy metabolism. The study involves using genetically modified mice to observe the effects of depleting the immunoproteasome in the liver, which has shown promising results in protecting against obesity and metabolic issues. The findings could lead to new insights into treating metabolic and autoimmune diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with metabolic disorders, autoimmune diseases, or chronic inflammation.
Not a fit: Patients with non-inflammatory metabolic conditions or those not affected by autoimmune diseases may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for managing metabolic disorders and autoimmune diseases.
How similar studies have performed: Previous studies have shown that targeting the immunoproteasome can lead to significant improvements in metabolic health, indicating a promising avenue for further exploration.
Where this research is happening
Minneapolis, United States
- University of Minnesota — Minneapolis, United States (Active)
Researchers
- Principal investigator: Kim, Do-Hyung — University of Minnesota
- Study coordinator: Kim, Do-Hyung
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.