Understanding how the immune system tolerates food and microbes in the large intestine
Local immune tolerance in the large intestine mediated by GPR15
This study is looking at how the immune system in your gut keeps things calm and prevents inflammation from food and germs, focusing on special cells called Tregs and a receptor named GPR15, which could help improve treatments for conditions like celiac disease and inflammatory bowel diseases.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Thomas Jefferson University NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-10763390 on NIH RePORTER |
What this research studies
This research investigates how the immune system in the large intestine prevents harmful inflammatory responses to dietary and microbial antigens. It focuses on the role of regulatory T cells (Tregs) and a specific receptor called GPR15 in maintaining immune tolerance. By studying how Tregs are activated and retained in the large intestine, the research aims to uncover mechanisms that could lead to better management of autoimmune conditions like celiac disease and inflammatory bowel diseases. Patients may benefit from insights that could lead to new treatments or dietary recommendations.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals suffering from autoimmune conditions such as celiac disease or inflammatory bowel diseases.
Not a fit: Patients with non-autoimmune gastrointestinal disorders may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for autoimmune diseases affecting the intestine, enhancing patient quality of life.
How similar studies have performed: Previous research has shown promising results in understanding immune tolerance mechanisms, suggesting that this approach could yield valuable insights.
Where this research is happening
Philadelphia, United States
- Thomas Jefferson University — Philadelphia, United States (Active)
Researchers
- Principal investigator: Kim, Sangwon Vincent — Thomas Jefferson University
- Study coordinator: Kim, Sangwon Vincent
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.