Understanding how the immune system responds to sepsis and its effects on the lungs
Host Immunity in Sepsis-Induced Systemic Infection
This study is looking at how the immune system reacts during sepsis and how this can lead to serious breathing problems, with the goal of finding new treatments that could help patients recover better from severe infections.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Louisiana State Univ A&m Col Baton Rouge NIH-funded |
| Lab location | 1 site (Baton Rouge, United States) |
| Project ID | NIH-11087678 on NIH RePORTER |
What this research studies
This research investigates the immune response during sepsis, particularly how it leads to complications like Acute Lung Injury (ALI) and Acute Respiratory Distress Syndrome (ARDS). The study focuses on the role of immune cells, specifically neutrophils, and how their excessive activity can cause damage to organs. By examining the mechanisms of immune recognition and activation, the research aims to identify potential therapies that could improve patient outcomes during severe bacterial infections. Patients may benefit from insights that could lead to new treatment strategies targeting the immune response.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults experiencing sepsis, particularly those showing signs of Acute Lung Injury or Acute Respiratory Distress Syndrome.
Not a fit: Patients with sepsis who do not exhibit lung complications may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment options for patients suffering from sepsis and its associated lung complications.
How similar studies have performed: Previous research has shown promise in understanding immune responses in sepsis, but this specific approach focusing on inflammasome activation is relatively novel.
Where this research is happening
Baton Rouge, United States
- Louisiana State Univ A&m Col Baton Rouge — Baton Rouge, United States (Active)
Researchers
- Principal investigator: Jeyaseelan, Samithamby — Louisiana State Univ A&m Col Baton Rouge
- Study coordinator: Jeyaseelan, Samithamby
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.