Understanding how the immune system quickly fights off infections
Official title: Dissecting how rapid microbial pathogen containment occurs in vivo
Funded at Albert Einstein College of Medicine · NIH-11138465 · Data updated 2026-11-12
This study looks at how a special type of immune cell helps fight off infections from germs like bacteria and viruses, and it aims to find ways to boost these cells' ability to protect people from getting sick.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Albert Einstein College of Medicine NIH-funded |
| Lab location | 1 site (Bronx, United States) |
| Project start | January 14, 2025 |
| Project end | December 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $244,440 |
| NIH project number | 1R21AI186033-01A1 |
| Project ID | NIH-11138465 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with acute bacterial infections or those at risk of severe infections.
✕Less likely to help
Patients with chronic infections or those who do not have an active immune response may not benefit from this research.
What this research studies
This research investigates how a specific type of immune cell, called Ly6C+ monocytes, responds to various microbial infections, including bacteria and viruses. The study focuses on how these cells are mobilized from the bone marrow to the site of infection, where they cluster and perform essential functions to eliminate pathogens. By using advanced imaging techniques in animal models, the researchers aim to uncover the mechanisms that guide these immune cells to effectively combat infections. This knowledge could lead to new strategies for enhancing immune responses in patients.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for infections by enhancing the body's natural immune response.
How similar studies have gone: Previous research has shown promising results in understanding immune cell behavior during infections, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Albert Einstein College of Medicine
Bronx, United States Active
Researchers
- Principal investigator: Lauvau, Gregoire Stephane — Albert Einstein College of Medicine
- Study coordinator: Lauvau, Gregoire Stephane
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.