Understanding how the immune system helps heal heart injuries
Innate immune response signaling in cardiac injury healing
['FUNDING_R01'] · CINCINNATI CHILDRENS HOSP MED CTR · NIH-10996108
This study is looking at how certain cells in your body can help heal heart injuries, like those from a heart attack, by boosting the immune response, and it’s for anyone interested in improving recovery after heart damage.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | CINCINNATI CHILDRENS HOSP MED CTR (nih funded) |
| Locations | 1 site (CINCINNATI, UNITED STATES) |
| Trial ID | NIH-10996108 on ClinicalTrials.gov |
What this research studies
This research investigates the role of the innate immune response in healing heart injuries caused by conditions like myocardial infarction. It focuses on how certain progenitor cells can influence the immune response to improve healing in the heart. By injecting these cells into the heart after injury, the study aims to enhance recovery and reduce damage. The approach involves examining the interactions between these cells and immune cells to optimize healing processes.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults who have experienced a myocardial infarction or other forms of cardiac injury.
Not a fit: Patients with chronic heart conditions unrelated to acute injuries may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that significantly improve heart recovery and function after injury.
How similar studies have performed: Previous studies have shown promising results in animal models, indicating that enhancing the immune response can aid in heart healing, although this specific approach is still being explored.
Where this research is happening
CINCINNATI, UNITED STATES
- CINCINNATI CHILDRENS HOSP MED CTR — CINCINNATI, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MOLKENTIN, JEFFERY D — CINCINNATI CHILDRENS HOSP MED CTR
- Study coordinator: MOLKENTIN, JEFFERY D
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Atherosclerotic Cardiovascular Disease, atherosclerotic disease