Understanding how the immune system fights infections during pregnancy
Immune Control of Group B Streptococcal Placental
['FUNDING_R01'] · SEATTLE CHILDREN'S HOSPITAL · NIH-10687155
This study is looking at how pregnant women and their babies' placentas fight off infections from a common bacteria called Group B Streptococcus, to help find better ways to keep both moms and their little ones safe during pregnancy.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | SEATTLE CHILDREN'S HOSPITAL (nih funded) |
| Locations | 1 site (SEATTLE, UNITED STATES) |
| Trial ID | NIH-10687155 on ClinicalTrials.gov |
What this research studies
This research investigates the immune responses of pregnant women and their placentas to bacterial infections, specifically focusing on Group B Streptococcus. By using a unique model that mimics human pregnancy, the study aims to identify the immune mechanisms that help clear these infections at the maternal-fetal interface. The researchers will employ advanced techniques such as flow cytometry and single-cell RNA sequencing to analyze immune cell populations and their functions. This work is crucial for understanding how to protect both mothers and their babies from serious complications related to infections during pregnancy.
Who could benefit from this research
Good fit: Ideal candidates for this research include pregnant women who are at risk for bacterial infections or have experienced complications in previous pregnancies.
Not a fit: Patients who are not pregnant or those who do not have a history of bacterial infections during pregnancy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing preterm birth and other complications associated with bacterial infections during pregnancy.
How similar studies have performed: Previous research has shown promise in understanding immune responses in pregnancy, but this specific approach using a nonhuman primate model is relatively novel.
Where this research is happening
SEATTLE, UNITED STATES
- SEATTLE CHILDREN'S HOSPITAL — SEATTLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: RAJAGOPAL, LAKSHMI — SEATTLE CHILDREN'S HOSPITAL
- Study coordinator: RAJAGOPAL, LAKSHMI
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Bacterial Infections, bacteria infection, bacterial disease