Understanding how the immune system fights infections
Official title: Mechanisms coordinating the local and systemic resistance to pathogens
Funded at University of Maryland Baltimore · NIH-10974032 · Data updated 2026-11-12
This study is looking at how certain immune cells help the body prepare to fight infections that can spread, with the goal of finding better ways to treat bacterial infections and similar illnesses that could help patients like you.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Maryland Baltimore NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | November 2, 2022 |
| Project end | October 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $578,188 |
| NIH project number | 5R01AI168192-03 |
| Project ID | NIH-10974032 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with acute bacterial infections or those at risk of systemic infections.
✕Less likely to help
Patients with chronic infections or those who do not have an active immune response may not benefit from this research.
What this research studies
This research investigates how the immune system coordinates its response to infections that can spread throughout the body. It focuses on the role of specific immune cells, particularly dendritic cells, in preparing distant tissues to respond to pathogens. By studying the communication between these cells and their signaling mechanisms, the research aims to uncover new ways to enhance the body's defense against infections. Patients may benefit from insights that could lead to improved treatments for bacterial infections and related diseases.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for enhancing the immune response to infections, potentially improving patient outcomes.
How similar studies have gone: Other research has shown promise in understanding immune responses to infections, but this specific approach to coordinating local and systemic immunity is relatively novel.
Where this research is happening
-
University of Maryland Baltimore
Baltimore, United States Active
Researchers
- Principal investigator: Singh, Nevil John — University of Maryland Baltimore
- Study coordinator: Singh, Nevil John
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.