Understanding how the immune system controls Yersinia infections
Dissecting innate immune control of intestinal and systemic Yersinia infection
['FUNDING_R01'] · UNIVERSITY OF PENNSYLVANIA · NIH-11166910
This study is looking at how your immune system fights off infections from Yersinia bacteria, especially how certain immune cells work together to form protective clusters in your body, which could help us find better ways to treat these infections.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF PENNSYLVANIA (nih funded) |
| Locations | 1 site (PHILADELPHIA, UNITED STATES) |
| Trial ID | NIH-11166910 on ClinicalTrials.gov |
What this research studies
This research investigates how the immune system responds to infections caused by Yersinia bacteria, focusing on the formation of granulomas, which are clusters of immune cells that help contain the infection. The study examines the role of specific immune cells, particularly inflammatory monocytes and neutrophils, in controlling the infection and forming organized structures called pyogranulomas in the intestines and other tissues. By analyzing these immune responses, the research aims to uncover new insights into how the body fights off these infections and the potential for developing better treatments.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with acute Yersinia infections or those at risk of such infections.
Not a fit: Patients with infections caused by other types of bacteria unrelated to Yersinia may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for treating infections caused by antibiotic-resistant Yersinia bacteria.
How similar studies have performed: Previous research has shown success in understanding immune responses to bacterial infections, making this approach promising but still exploring novel aspects of Yersinia infections.
Where this research is happening
PHILADELPHIA, UNITED STATES
- UNIVERSITY OF PENNSYLVANIA — PHILADELPHIA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BRODSKY, IGOR E — UNIVERSITY OF PENNSYLVANIA
- Study coordinator: BRODSKY, IGOR E
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: bacteria infection, bacterial disease, Bacterial Infections