Understanding how the immune system controls Yersinia infections
Official title: Dissecting innate immune control of intestinal and systemic Yersinia infection
Funded at University of Pennsylvania · NIH-11166910 · Data updated 2026-11-12
This study is looking at how your immune system fights off infections from Yersinia bacteria, especially how certain immune cells work together to form protective clusters in your body, which could help us find better ways to treat these infections.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | March 3, 2025 |
| Project end | February 28, 2030 |
| Funding year | 2025 |
| Award (this year) | $1,024,897 |
| NIH project number | 1R01AI191440-01 |
| Project ID | NIH-11166910 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with acute Yersinia infections or those at risk of such infections.
✕Less likely to help
Patients with infections caused by other types of bacteria unrelated to Yersinia may not benefit from this research.
What this research studies
This research investigates how the immune system responds to infections caused by Yersinia bacteria, focusing on the formation of granulomas, which are clusters of immune cells that help contain the infection. The study examines the role of specific immune cells, particularly inflammatory monocytes and neutrophils, in controlling the infection and forming organized structures called pyogranulomas in the intestines and other tissues. By analyzing these immune responses, the research aims to uncover new insights into how the body fights off these infections and the potential for developing better treatments.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for treating infections caused by antibiotic-resistant Yersinia bacteria.
How similar studies have gone: Previous research has shown success in understanding immune responses to bacterial infections, making this approach promising but still exploring novel aspects of Yersinia infections.
Where this research is happening
-
University of Pennsylvania
Philadelphia, United States Active
Researchers
- Principal investigator: Brodsky, Igor E — University of Pennsylvania
- Study coordinator: Brodsky, Igor E
Related research
Other NIH-funded projects on the same topics.
-
Comparing universal and guideline-directed genetic testing for young adults with cancer
This study is looking at whether a broader genetic test can help young adults with cancer find inherited risks that regular tests might miss, so they can get better treatment and care tailored just for them.
-
Better, searchable data for human pain biology
A data integration center will standardize, combine, and share molecular and cellular data from human pain research to help scientists understand how pain works and to accelerate discoveries.
-
Understanding how sweat glands form and work to help burn and skin injury patients
A study at the University of Pennsylvania looks at how sweat glands develop and function, with the goal of informing treatments for people who suffer traumatic skin injuries.
-
Cardiovascular risk planning and reduction for men with prostate cancer
A program to better predict and reduce heart disease risk in men treated for prostate cancer, especially older patients.
-
Understanding how a special airway cell helps protect and repair breathing passages
A researcher is studying a newly found airway cell called the hillock to see how it protects the airways and helps repair them after injury, with the aim of helping people with asthma, COPD, or bronchiectasis.
-
Defining TMJ cartilage progenitors and their regulatory niche for TMJ regeneration
Researchers are studying the cells that could help repair the jaw’s cartilage in TMJ osteoarthritis to lay the groundwork for regenerative therapies.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.