Understanding how the immune system clears bacterial infections
Official title: The molecular mechanism of Siglec-E in bacterial clearance
Funded at University of Tennessee Health Sci Ctr · NIH-11115748 · Data updated 2026-11-12
This study is looking at how a special immune receptor called Siglec-E helps our body fight off infections from bacteria like E. coli, with the goal of finding better ways to treat or prevent sepsis, a serious condition that can happen when infections get out of control.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Tennessee Health Sci Ctr NIH-funded |
| Lab location | 1 site (Memphis, United States) |
| Project start | June 13, 2024 |
| Project end | April 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $462,000 |
| NIH project number | 5R01AI179632-02 |
| Project ID | NIH-11115748 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals at risk of sepsis due to bacterial infections, particularly those caused by Gram-negative bacteria.
✕Less likely to help
Patients with sepsis caused by Gram-positive bacteria may not benefit directly from this research.
What this research studies
This research investigates the role of a specific immune receptor, Siglec-E, in the body's response to bacterial infections, particularly focusing on Gram-negative bacteria like E. coli. By studying how this receptor influences the immune response and the clearance of bacteria, the research aims to uncover new insights into treating or preventing sepsis, a severe and often life-threatening condition. The approach includes using animal models to observe the effects of Siglec-E on bacterial clearance and the production of reactive oxygen species, which are crucial for fighting infections.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for sepsis, potentially saving lives and reducing complications from bacterial infections.
How similar studies have gone: Previous studies have shown promising results in understanding immune responses to bacterial infections, indicating that this approach has potential for success.
Where this research is happening
-
University of Tennessee Health Sci Ctr
Memphis, United States Active
Researchers
- Principal investigator: Chen, Guoyun — University of Tennessee Health Sci Ctr
- Study coordinator: Chen, Guoyun
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.