Understanding how the immune system clears bacterial infections
The molecular mechanism of Siglec-E in bacterial clearance
['FUNDING_R01'] · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · NIH-11115748
This study is looking at how a special immune receptor called Siglec-E helps our body fight off infections from bacteria like E. coli, with the goal of finding better ways to treat or prevent sepsis, a serious condition that can happen when infections get out of control.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF TENNESSEE HEALTH SCI CTR (nih funded) |
| Locations | 1 site (MEMPHIS, UNITED STATES) |
| Trial ID | NIH-11115748 on ClinicalTrials.gov |
What this research studies
This research investigates the role of a specific immune receptor, Siglec-E, in the body's response to bacterial infections, particularly focusing on Gram-negative bacteria like E. coli. By studying how this receptor influences the immune response and the clearance of bacteria, the research aims to uncover new insights into treating or preventing sepsis, a severe and often life-threatening condition. The approach includes using animal models to observe the effects of Siglec-E on bacterial clearance and the production of reactive oxygen species, which are crucial for fighting infections.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at risk of sepsis due to bacterial infections, particularly those caused by Gram-negative bacteria.
Not a fit: Patients with sepsis caused by Gram-positive bacteria may not benefit directly from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for sepsis, potentially saving lives and reducing complications from bacterial infections.
How similar studies have performed: Previous studies have shown promising results in understanding immune responses to bacterial infections, indicating that this approach has potential for success.
Where this research is happening
MEMPHIS, UNITED STATES
- UNIVERSITY OF TENNESSEE HEALTH SCI CTR — MEMPHIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CHEN, GUOYUN — UNIVERSITY OF TENNESSEE HEALTH SCI CTR
- Study coordinator: CHEN, GUOYUN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: bacteria infection, bacterial disease, Bacterial Infections