Understanding how the immune system changes with age
High resolution longitudinal immune monitoring for elucidating immune aging dynamics
This study is looking at how our immune systems change as we get older, by following a group of both young and older people to see how their immune cells respond to vaccines and other factors, with the goal of creating a tool to help understand immune health and its impact on overall well-being.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project ID | NIH-10912722 on NIH RePORTER |
What this research studies
This research investigates the dynamics of immune system changes over time in both young and older individuals. By tracking a diverse cohort, the study analyzes immune cell types, responses to vaccinations, and other immune markers to create a comprehensive picture of immune aging. The researchers utilize advanced techniques to measure these changes, allowing for a deeper understanding of how aging affects immune function and its implications for health. This work aims to develop a metric called IMM-AGE, which reflects an individual's immune health and its relationship to overall mortality and disease risk.
Who could benefit from this research
Good fit: Ideal candidates for this research include healthy older adults aged 60 and above, as well as younger individuals aged 20-40 for comparative analysis.
Not a fit: Patients with acute illnesses or those who are not within the specified age ranges may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved methods for predicting health outcomes and early detection of diseases related to aging.
How similar studies have performed: Previous research has shown success in understanding immune aging dynamics, but this approach is novel in its longitudinal and high-resolution analysis.
Where this research is happening
Stanford, United States
- Stanford University — Stanford, United States (Active)
Researchers
- Principal investigator: Davis, Mark Morris — Stanford University
- Study coordinator: Davis, Mark Morris
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.