Understanding how the immune system attacks skin cells in vitiligo
Dissecting Functional Autoimmunity through High-Resolution Multiomics in a Vitiligo Center of Research Translation (V-CoRT)
This study is looking into how vitiligo works by examining skin samples from patients to see how the immune system affects the cells that give skin its color, with the hope of finding better treatments for vitiligo and similar conditions.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of Massachusetts Med Sch Worcester NIH-funded |
| Lab location | 1 site (Worcester, United States) |
| Project ID | NIH-10868476 on NIH RePORTER |
What this research studies
This research investigates the mechanisms behind vitiligo, an autoimmune disease where the immune system mistakenly targets skin cells responsible for pigmentation. By analyzing skin samples from patients, the study aims to uncover how immune cells interact with and destroy these pigment-producing cells. The approach involves high-resolution multiomics data to create a detailed communication network among various cell types involved in the disease. This comprehensive understanding could lead to better treatments for vitiligo and similar autoimmune conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with vitiligo, particularly those with visible skin lesions.
Not a fit: Patients with autoimmune diseases other than vitiligo or those without any skin manifestations may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved therapies for vitiligo and enhance our understanding of other autoimmune diseases.
How similar studies have performed: Previous research has shown promise in understanding autoimmune mechanisms through similar multiomics approaches, indicating potential for success in this study.
Where this research is happening
Worcester, United States
- Univ of Massachusetts Med Sch Worcester — Worcester, United States (Active)
Researchers
- Principal investigator: Harris, John E — Univ of Massachusetts Med Sch Worcester
- Study coordinator: Harris, John E
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.