Understanding how the Hsp90 chaperone helps proteins function in the body
Regulatory mechanisms of the Hsp90 chaperone machinery
This study is looking at how a special protein called Hsp90 helps other proteins work properly, which could improve treatments for cancer and autoimmune diseases, so patients might get better results from therapies that target Hsp90.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Upstate Medical University NIH-funded |
| Lab location | 1 site (Syracuse, United States) |
| Project ID | NIH-11005016 on NIH RePORTER |
What this research studies
This research investigates the regulatory mechanisms of the Heat Shock Protein-90 (Hsp90) chaperone, which is crucial for the proper functioning of various proteins involved in important cellular processes. By exploring how Hsp90 interacts with other proteins and is regulated by modifications, the research aims to enhance the effectiveness of Hsp90-targeted therapies currently being tested for conditions like cancer and autoimmune diseases. Patients may benefit from insights gained into optimizing these therapies, potentially leading to better treatment outcomes. The research employs biochemical assays and cellular models to dissect the complex interactions and regulatory pathways of Hsp90.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include individuals diagnosed with cancer or autoimmune diseases who may be eligible for Hsp90-targeted therapies.
Not a fit: Patients with conditions unrelated to the mechanisms of Hsp90 or those not eligible for Hsp90-targeted therapies may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved therapies for cancer and autoimmune diseases by optimizing the use of Hsp90 inhibitors.
How similar studies have performed: Previous research has shown promising results in targeting Hsp90 for cancer treatment, indicating that this approach has potential for success.
Where this research is happening
Syracuse, United States
- Upstate Medical University — Syracuse, United States (Active)
Researchers
- Principal investigator: Mollapour, Mehdi — Upstate Medical University
- Study coordinator: Mollapour, Mehdi
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.