Understanding how the extracellular matrix regulates cell behavior
Official title: In vivo regulation of the extracellular matrix
Funded at University of Wyoming · NIH-10875296 · Data updated 2026-11-12
This study looks at a special network of proteins that help shape and support cells, focusing on a part that's not well understood, to learn how it affects cell growth and development in tiny worms, which could help us understand its role in health and disease.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Wyoming NIH-funded |
| Lab location | 1 site (Laramie, United States) |
| Project start | July 1, 2020 |
| Project end | June 30, 2025 |
| Funding year | 2024 |
| Award (this year) | $536,174 |
| NIH project number | 5R35GM136236-05 |
| Project ID | NIH-10875296 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions related to tissue development or ECM dysfunction.
✕Less likely to help
Patients with conditions unrelated to ECM regulation or those not affected by developmental processes may not benefit from this research.
What this research studies
This research investigates the extracellular matrix (ECM), a crucial network of molecules surrounding cells that influences their organization and function. The focus is on the apical ECM, which is less understood compared to the basement membrane, and its role in processes like cell shape and tissue development. Using the model organism C. elegans, the study will explore how specific proteins regulate the aECM during embryonic development and larval molting. By uncovering these regulatory pathways, the research aims to enhance our understanding of ECM's impact on health and disease.
Why it matters
Potential benefit: If successful, this research could lead to new insights into how ECM regulation affects various diseases and developmental disorders.
How similar studies have gone: While the study of the apical ECM is relatively novel, previous research on ECM regulation has shown promising results in understanding cell behavior and disease mechanisms.
Where this research is happening
-
University of Wyoming
Laramie, United States Active
Researchers
- Principal investigator: Fay, David S — University of Wyoming
- Study coordinator: Fay, David S
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.