Ribosomal proteins and pseudogenes in stress-affected neurons
Official title: The neurobiology of ribosomal proteins and ribosomal-protein-pseudogenes
Funded at University of Wyoming · NIH-11388644 · Data updated 2026-11-12
This project looks at how stress changes the proteins that make up ribosomes in brain cells, which could reveal new ways stress affects nervous system health.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Wyoming NIH-funded |
| Lab location | 1 site (Laramie, United States) |
| Project start | September 1, 2017 |
| Project end | July 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $208,058 |
| NIH project number | 5P20GM121310-10 |
| Project ID | NIH-11388644 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are individuals with/needing research that translates to stress-related neurological conditions; however, this grant uses mouse and cell models, not direct patient recruitment.
✕Less likely to help
Patients will not be enrolled in this study as described; it uses animal and cell models.
What this research studies
Researchers will study stressed neurons from mice to see if ribosomal proteins and related pseudogenes change the ribosome’s makeup. They will separate neuron cell bodies from their projections using a specialized culture setup and use advanced proteomics to measure protein composition. They will also combine ribosome sequencing with RNA sequencing to understand how pseudogenes might be incorporated into ribosomes during stress. The goal is to link molecular changes in ribosome biology to neuronal stress responses that could affect brain function.
Why it matters
Potential benefit: Understanding ribosome changes under stress could identify new targets for preventing or mitigating stress-related brain conditions.
How similar studies have gone: Previous work has shown ribosome biology can change under stress, but linking this to neuronal compartments and pseudogene involvement is a newer approach.
Where this research is happening
-
University of Wyoming
Laramie, United States Active
Researchers
- Principal investigator: Shukla, Rammohan — University of Wyoming
- Study coordinator: Shukla, Rammohan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.