Understanding how the endoplasmic reticulum protects liver cells from lipid overload
Lipotoxic Protective Response of the Endoplasmic Reticulum
['FUNDING_R01'] · SLOAN-KETTERING INST CAN RESEARCH · NIH-10768643
This study is looking at how a special protein called FIT2 helps liver cells keep a healthy balance of fats, which is important for preventing liver diseases like cancer, and it hopes to find new ways to help people manage or avoid these conditions.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | SLOAN-KETTERING INST CAN RESEARCH (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-10768643 on ClinicalTrials.gov |
What this research studies
This research investigates the role of the endoplasmic reticulum (ER) in maintaining lipid balance within liver cells, which is crucial for preventing diseases related to lipid overload, such as liver cancer. The study focuses on a newly identified protein, FIT2, which is essential for lipid metabolism and cell health. By exploring how FIT2 functions and contributes to the protective response against lipid-induced stress, the research aims to uncover new therapeutic targets for liver-related disorders. Patients may benefit from insights gained into how to better manage or prevent liver diseases linked to lipid imbalances.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at risk for liver diseases, particularly those with conditions related to lipid overload, such as obesity or metabolic syndrome.
Not a fit: Patients with liver diseases not related to lipid metabolism or those with advanced liver failure may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating liver diseases, including liver cancer, by targeting lipid metabolism.
How similar studies have performed: Other research has shown promising results in understanding lipid metabolism and its implications for liver health, suggesting that this approach has potential for success.
Where this research is happening
NEW YORK, UNITED STATES
- SLOAN-KETTERING INST CAN RESEARCH — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: FARESE, ROBERT V — SLOAN-KETTERING INST CAN RESEARCH
- Study coordinator: FARESE, ROBERT V
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Hepatic Cancer, liver cancer