Understanding how the brain controls vocalization in mice
Official title: The brainstem vocal control circuits
Funded at Massachusetts Institute of Technology · NIH-11140506 · Data updated 2026-11-12
This study is looking at how certain brain cells in mice help them make different sounds, like high-pitched calls and squeaks, to better understand how communication works, which could also give us clues about how humans control their voices.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts Institute of Technology NIH-funded |
| Lab location | 1 site (Cambridge, United States) |
| Project start | August 1, 2024 |
| Project end | May 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $558,565 |
| NIH project number | 5R01DC021970-02 |
| Project ID | NIH-11140506 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research would include individuals with vocalization or communication disorders.
✕Less likely to help
Patients who do not have any vocalization or communication issues may not receive direct benefits from this research.
What this research studies
This research investigates the brain circuits involved in vocalization, focusing on how specific neurons control different types of sounds in mice. By examining the brainstem and its connections, the study aims to identify the neuronal cell types responsible for producing ultrasonic vocalizations and audible squeaks. The researchers will use advanced techniques to map these circuits and understand their functions, which could provide insights into the neural mechanisms of communication. This work may help in understanding vocal control in other species, including humans.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of vocal communication disorders and lead to new treatments for conditions affecting speech.
How similar studies have gone: Previous research has shown promise in understanding vocal control mechanisms in other species, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Massachusetts Institute of Technology
Cambridge, United States Active
Researchers
- Principal investigator: Wang, Fan — Massachusetts Institute of Technology
- Study coordinator: Wang, Fan
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.