Understanding how the brain and immune system interact after a heart attack
Brain-immune crosstalk in myocardial infarction
This study is looking at how the brain and immune system work together after a heart attack to help improve recovery and long-term health, and it’s for people who have had a heart attack to see how stress and inflammation might affect their healing.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10832050 on NIH RePORTER |
What this research studies
This research investigates the communication between the brain and the immune system following a heart attack, known as myocardial infarction (MI). It aims to understand how different brain regions influence the immune response and healing process after MI, which can significantly affect recovery and long-term health. By examining the role of stress and inflammation, the study seeks to identify potential therapeutic targets that could improve outcomes for heart attack survivors. Patients may be monitored for changes in immune function and brain activity during recovery.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals who have recently experienced a myocardial infarction and are undergoing recovery.
Not a fit: Patients who have not experienced a myocardial infarction or those with chronic heart conditions unrelated to acute events may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance recovery and quality of life for heart attack survivors.
How similar studies have performed: Previous research has shown promising results in understanding the brain-immune connection in other conditions, suggesting that this approach may yield valuable insights for myocardial infarction as well.
Where this research is happening
Boston, United States
- Massachusetts General Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Poller, Wolfram Christian — Massachusetts General Hospital
- Study coordinator: Poller, Wolfram Christian
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.