Understanding how the body's defenses against viruses are controlled by RNA and proteins
Regulation of the MAVS Signalosome by RNA and RNA-binding Proteins
This research explores how our immune system responds to viruses and how this process might lead to autoimmune diseases.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cincinnati Childrens Hosp Med Ctr NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project ID | NIH-11140815 on NIH RePORTER |
What this research studies
Our bodies have a natural defense system that fights off viruses, but sometimes this system can become overactive and cause autoimmune diseases. This project looks at a key part of this defense, called the MAVS pathway, which helps our cells produce protective signals when they detect viral RNA. We are learning how different types of RNA and specific proteins interact with the MAVS pathway to either boost or calm down the immune response. By understanding these interactions, we hope to uncover why some immune responses go awry and contribute to autoimmune conditions.
Who could benefit from this research
Good fit: This foundational laboratory research does not involve direct patient participation but aims to benefit individuals with autoimmune diseases in the future.
Not a fit: Patients not affected by autoimmune conditions or viral immune responses are unlikely to see direct benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to a deeper understanding of autoimmune diseases and new ways to manage or prevent them by better controlling the body's immune response.
How similar studies have performed: This project explores novel roles for RNA and RNA-binding proteins in the MAVS pathway, building on existing knowledge of immune signaling but venturing into new territory.
Where this research is happening
Cincinnati, United States
- Cincinnati Childrens Hosp Med Ctr — Cincinnati, United States (Active)
Researchers
- Principal investigator: Gokhale, Nandan Satish — Cincinnati Childrens Hosp Med Ctr
- Study coordinator: Gokhale, Nandan Satish
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.