Understanding how the body responds to stress from infections
Response to Immune Associated Stress
This study is looking at how our bodies handle stress when we're sick, especially focusing on certain proteins that help keep us safe during infections, and it hopes to find new ways to help people with autoimmune and infectious diseases feel better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Sci Ctr Houston NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-10769828 on NIH RePORTER |
What this research studies
This research investigates the mechanisms by which the body manages stress during infections, focusing on specific proteins that help regulate this response. It aims to uncover how these proteins, particularly Nrf1/2 and SKN-1, interact to protect the body from immune-related stress. By identifying new factors that influence these proteins, the research seeks to find potential therapeutic targets that could alleviate the negative effects of infections. Patients may benefit from insights that could lead to new treatments for autoimmune and infectious diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals suffering from autoimmune diseases or those with recurrent infections.
Not a fit: Patients with non-infectious conditions or those not affected by autoimmune disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that improve the body's ability to cope with infections and reduce the severity of autoimmune conditions.
How similar studies have performed: Previous research has shown promise in understanding immune responses, but this specific approach to regulating stress responses during infections is relatively novel.
Where this research is happening
Houston, United States
- University of Texas Hlth Sci Ctr Houston — Houston, United States (Active)
Researchers
- Principal investigator: Garsin, Danielle a — University of Texas Hlth Sci Ctr Houston
- Study coordinator: Garsin, Danielle a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.