Understanding how the body repairs itself after influenza A pneumonia
Project 2: Metabolic regulation of host response and repair mechanisms to influenza A viral pneumonia
This study is looking at why some people have a hard time healing their lungs after getting sick with influenza A pneumonia, and it aims to find ways to help improve recovery for patients by understanding how inflammation and certain cell functions play a role in the healing process.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Northwestern University at Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project ID | NIH-10910889 on NIH RePORTER |
What this research studies
This research investigates the mechanisms that hinder tissue repair following influenza A viral pneumonia, a leading cause of death worldwide. It focuses on the role of inflammation and specific cellular processes that affect recovery in patients. By examining the inflammasome complex and mitochondrial function, the study aims to identify potential therapeutic targets that could enhance lung repair and improve patient outcomes. The approach includes both laboratory experiments and analysis of patient samples to understand the biological responses involved.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have experienced influenza A pneumonia and are facing challenges in recovery.
Not a fit: Patients who have not been diagnosed with influenza A pneumonia or those with chronic respiratory conditions unrelated to viral infections may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved survival rates and reduced long-term complications for patients recovering from influenza A pneumonia.
How similar studies have performed: Previous research has shown promise in targeting inflammatory pathways for improving recovery from viral infections, suggesting that this approach could yield significant insights.
Where this research is happening
Chicago, United States
- Northwestern University at Chicago — Chicago, United States (Active)
Researchers
- Principal investigator: Chandel, Navdeep S — Northwestern University at Chicago
- Study coordinator: Chandel, Navdeep S
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.