Understanding how the body controls its defenses against viruses
Regulation of innate antiviral responses by the DNA-binding transcriptional repressor complex CIC-ATXN1/L
This research aims to understand how our immune system balances fighting off viruses with preventing overreactions that can lead to autoimmune diseases.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Iowa NIH-funded |
| Lab location | 1 site (Iowa City, United States) |
| Project ID | NIH-11134624 on NIH RePORTER |
What this research studies
Our bodies have a natural defense system that fights viruses, but if this system is too active, it can cause problems like autoimmune diseases. This project focuses on a specific protein, called CIC, which appears to help keep these defenses in check. By studying how CIC works, we hope to learn more about how our immune system is regulated. This knowledge could help us find new ways to treat conditions where the immune system is either too weak or too strong.
Who could benefit from this research
Good fit: This foundational research is relevant to individuals living with autoimmune diseases or those who experience chronic viral infections.
Not a fit: Patients without conditions related to immune system dysregulation or chronic viral infections may not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to a deeper understanding of immune system regulation, potentially paving the way for new treatments for autoimmune diseases and chronic viral infections.
How similar studies have performed: This project identifies CIC as a novel regulator of innate immune responses, building upon existing knowledge of its role in other biological processes.
Where this research is happening
Iowa City, United States
- University of Iowa — Iowa City, United States (Active)
Researchers
- Principal investigator: Manicassamy, Balaji — University of Iowa
- Study coordinator: Manicassamy, Balaji
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.