Understanding how the body clears dying cells and its impact on autoimmune diseases.
Rethinking the "quiet" nature of apoptotic cell clearance.
This study is looking at how our immune cells, called macrophages, help clean up dead cells in the body and how problems with this process might lead to autoimmune and inflammatory diseases, so it's for anyone interested in understanding these conditions better.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Sloan-Kettering Inst Can Research NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11014641 on NIH RePORTER |
What this research studies
This research investigates the process of efferocytosis, where the body clears dead cells, and how this process may influence autoimmune and inflammatory diseases. It focuses on the role of macrophages, a type of immune cell, in managing the digestion of apoptotic cells and the potential dangers associated with this process. By developing a new model, the research aims to uncover how disruptions in macrophage function can lead to autoimmune conditions, rather than simply a failure to clear dead cells. The study employs innovative methodologies to explore the rapid response mechanisms that macrophages use to handle the contents of engulfed cells.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from autoimmune diseases or inflammatory conditions.
Not a fit: Patients with acute infections or those not experiencing autoimmune or inflammatory symptoms may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for preventing or treating autoimmune and inflammatory diseases.
How similar studies have performed: Other research has indicated that understanding the mechanisms of cell clearance can significantly impact the treatment of autoimmune diseases, suggesting this approach has potential for success.
Where this research is happening
New York, United States
- Sloan-Kettering Inst Can Research — New York, United States (Active)
Researchers
- Principal investigator: Perry, Justin S — Sloan-Kettering Inst Can Research
- Study coordinator: Perry, Justin S
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.