Understanding how the bladder protects against urinary tract infections
Urothelial IL-6 Signaling in the Host Defense Against Urinary Tract Infections
['FUNDING_CAREER'] · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · NIH-10615681
This study is looking at how a part of your bladder helps fight off urinary tract infections (UTIs) by focusing on a substance called IL-6, with the goal of finding new ways to prevent and treat UTIs, especially as antibiotics become less effective.
Quick facts
| Phase | ['FUNDING_CAREER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | RESEARCH INST NATIONWIDE CHILDREN'S HOSP (nih funded) |
| Locations | 1 site (COLUMBUS, UNITED STATES) |
| Trial ID | NIH-10615681 on ClinicalTrials.gov |
What this research studies
This research investigates the role of the bladder lining in defending against urinary tract infections (UTIs), particularly focusing on the cytokine interleukin-6 (IL-6). The study aims to uncover how IL-6 activates specific pathways that help clear harmful bacteria, such as E. coli, from the urinary tract. By exploring these mechanisms, the research seeks to identify new therapeutic strategies that could complement or replace traditional antibiotic treatments, especially in the face of rising antibiotic resistance. Patients may benefit from insights that could lead to innovative prevention and treatment options for UTIs.
Who could benefit from this research
Good fit: Ideal candidates for this research include children and young adults who experience recurrent urinary tract infections.
Not a fit: Patients with UTIs caused by non-E. coli pathogens or those who do not experience recurrent infections may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance the body's natural defenses against urinary tract infections, reducing reliance on antibiotics.
How similar studies have performed: Previous research has shown promise in exploring innate immune responses to bacterial infections, suggesting that this approach could yield valuable insights.
Where this research is happening
COLUMBUS, UNITED STATES
- RESEARCH INST NATIONWIDE CHILDREN'S HOSP — COLUMBUS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CHING, CHRISTINA B — RESEARCH INST NATIONWIDE CHILDREN'S HOSP
- Study coordinator: CHING, CHRISTINA B
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Bacterial Infections, bacteria infection, bacterial disease