Understanding how the arrangement of brain receptors affects their function
Evaluating the functional impact of synaptic nanoarchitecture
['FUNDING_R01'] · UNIVERSITY OF COLORADO DENVER · NIH-11003716
This study is looking at how the tiny positions of brain receptors affect how well our brain cells communicate, which is important for understanding and potentially treating brain disorders.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF COLORADO DENVER (nih funded) |
| Locations | 1 site (Aurora, UNITED STATES) |
| Trial ID | NIH-11003716 on ClinicalTrials.gov |
What this research studies
This research investigates the role of nanoscale positioning of neurotransmitter receptors in synaptic function, which is crucial for understanding various brain disorders. The team will develop innovative methods to manipulate and measure the arrangement of these receptors in real-time, allowing them to explore how this positioning impacts synaptic transmission. By examining the relationship between receptor activation and their distance from neurotransmitter release sites, the research aims to uncover new insights into synaptic dysfunction. This could lead to better understanding and potential treatments for brain diseases linked to synaptic issues.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with brain disorders that involve synaptic transmission issues.
Not a fit: Patients with non-neurological conditions or those whose brain disorders are unrelated to synaptic function may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for treating brain disorders caused by synaptic dysfunction.
How similar studies have performed: While the specific approach of manipulating synaptic nanoarchitecture is novel, related research has shown promising results in understanding synaptic function and its implications for brain health.
Where this research is happening
Aurora, UNITED STATES
- UNIVERSITY OF COLORADO DENVER — Aurora, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: KENNEDY, MATTHEW J — UNIVERSITY OF COLORADO DENVER
- Study coordinator: KENNEDY, MATTHEW J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Brain Diseases, Brain Disorders