Understanding how the anterior cingulate cortex affects cognitive control in the brain
Official title: Investigation of Anterior Cingulate Cortex Contributions to Hippocampal Cognitive Control
Funded at New York University · NIH-10933450 · Data updated 2026-11-12
This study is looking at how a part of the brain called the anterior cingulate cortex helps with decision-making and staying focused, using rats to see how this area works when they navigate tasks, and it will also check what happens when this part of the brain is temporarily turned off.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | November 1, 2023 |
| Project end | October 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $74,284 |
| NIH project number | 5F32MH135680-02 |
| Project ID | NIH-10933450 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research would be individuals with cognitive control challenges, such as those with neurological disorders affecting decision-making.
✕Less likely to help
Patients with conditions unrelated to cognitive control or those who do not exhibit cognitive impairments may not benefit from this research.
What this research studies
This research investigates the role of the anterior cingulate cortex (ACC) in cognitive control, which is essential for making decisions and monitoring performance. Using advanced techniques like in-vivo single photon calcium imaging, the study will observe neuron activity in the ACC while rats engage in tasks that require navigation and cognitive control. Additionally, the research will employ chemogenetic methods to temporarily deactivate the ACC to assess its necessity during these tasks. The findings aim to clarify how the ACC contributes to cognitive control alongside the hippocampus.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of cognitive control mechanisms, potentially leading to improved treatments for cognitive impairments.
How similar studies have gone: Previous research has shown promising results in understanding cognitive control through similar methodologies, indicating a potential for success in this investigation.
Where this research is happening
-
New York University
New York, United States Active
Researchers
- Principal investigator: Blair, Garrett — New York University
- Study coordinator: Blair, Garrett
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.