Understanding how the amygdala affects compulsive behaviors in the brain
Direct amygdala modulation of the dorsolateral striatum and compulsive behaviors
This study is looking at how a part of the brain called the amygdala might affect certain repetitive movements that some people experience, especially those with neurological or mental health conditions, to help find new ways to treat these behaviors.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | State University New York Stony Brook NIH-funded |
| Lab location | 1 site (Stony Brook, United States) |
| Project ID | NIH-10452575 on NIH RePORTER |
What this research studies
This research investigates the relationship between the amygdala and the dorsolateral striatum, focusing on how signals from the amygdala may influence compulsive motor behaviors. By examining the brain circuits involved, the study aims to uncover the mechanisms that lead to these behaviors, which are common in various neurological and psychiatric disorders. The research employs advanced techniques to analyze synaptic inputs and their effects on motor function, potentially leading to new therapeutic targets for treatment.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals experiencing compulsive motor behaviors associated with anxiety disorders or other neuropsychiatric conditions.
Not a fit: Patients without compulsive motor behaviors or those not affected by anxiety disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for patients suffering from compulsive motor behaviors and related disorders.
How similar studies have performed: Previous research has shown promising results in understanding the brain circuits involved in compulsive behaviors, suggesting that this approach may yield valuable insights.
Where this research is happening
Stony Brook, United States
- State University New York Stony Brook — Stony Brook, United States (Active)
Researchers
- Principal investigator: Plotkin, Joshua L — State University New York Stony Brook
- Study coordinator: Plotkin, Joshua L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.