Understanding how the ACL behaves during movement and what increases injury risk
In vivo ACL mechanics and risk factors for injury
['FUNDING_R01'] · DUKE UNIVERSITY · NIH-11078244
This study looks at how the ACL behaves during activities like jumping and cutting to understand why injuries happen, especially for women and those who have hurt their ACL before, so we can find better ways to prevent and treat these injuries.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | DUKE UNIVERSITY (nih funded) |
| Locations | 1 site (DURHAM, UNITED STATES) |
| Trial ID | NIH-11078244 on ClinicalTrials.gov |
What this research studies
This research investigates the mechanics of the anterior cruciate ligament (ACL) during dynamic activities like jumping and cutting, which are common causes of ACL injuries. By using advanced 3-D modeling techniques, the study aims to identify specific risk factors that contribute to non-contact ACL injuries, particularly in populations at higher risk, such as females and individuals with previous ACL injuries. The research will analyze how the ACL elongates under tension during these movements, providing insights into injury vulnerability. This information could lead to better prevention strategies and rehabilitation protocols for those at risk of ACL injuries.
Who could benefit from this research
Good fit: Ideal candidates for this research include athletes, particularly females and individuals with a history of ACL injuries, who are at higher risk for non-contact ACL injuries.
Not a fit: Patients who have already undergone ACL reconstruction and are not involved in high-risk activities may not benefit directly from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved prevention and treatment strategies for ACL injuries, potentially reducing the incidence of these injuries and associated long-term complications like osteoarthritis.
How similar studies have performed: Previous research has shown promising results in understanding ACL mechanics and injury risk factors, suggesting that this approach could yield valuable insights.
Where this research is happening
DURHAM, UNITED STATES
- DUKE UNIVERSITY — DURHAM, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: DEFRATE, LOUIS E. — DUKE UNIVERSITY
- Study coordinator: DEFRATE, LOUIS E.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: ACL injury, anterior cruciate ligament injury