Understanding how telomeres function in human cells
Official title: Molecular mechanisms of intersecting human telomeric functions
Funded at University of Michigan at Ann Arbor · NIH-11030290 · Data updated 2026-11-12
This study is looking at how certain proteins help protect our chromosomes and support healthy cell division, which could lead to better understanding of cancer and reproductive health for people who are affected by these issues.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project start | February 6, 2023 |
| Project end | January 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $340,833 |
| NIH project number | 5R35GM148276-03 |
| Project ID | NIH-11030290 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with cancer or those experiencing difficulties conceiving, particularly if these issues are linked to telomere dysfunction.
✕Less likely to help
Patients with conditions unrelated to telomere function or those who are not experiencing any reproductive or cancer-related issues may not benefit from this research.
What this research studies
This research investigates the molecular mechanisms behind telomeres, which are protective structures at the ends of chromosomes. It focuses on how telomeres prevent chromosome damage, facilitate cell replication, and assist in the production of gametes. By studying a specific protein complex called shelterin and its interactions with telomerase, the research aims to uncover how these processes are regulated during cell division. This could provide insights into conditions related to cancer and reproductive health.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for cancer and improve understanding of fertility issues related to telomere dysfunction.
How similar studies have gone: Previous research has shown promising results in understanding telomere biology, indicating that this area of study has the potential for significant breakthroughs.
Where this research is happening
-
University of Michigan at Ann Arbor
Ann Arbor, United States Active
Researchers
- Principal investigator: Nandakumar, Jayakrishnan — University of Michigan at Ann Arbor
- Study coordinator: Nandakumar, Jayakrishnan
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.