Understanding how TAM receptors work in the body
The Structural Basis of TAM Receptor Oligomerizarion and Co-receptor Interactions
['FUNDING_OTHER'] · UNIV OF NORTH CAROLINA CHAPEL HILL · NIH-11012380
This study is looking at special proteins called TAM receptors that help keep our immune system and cells healthy, and it hopes to find new ways to treat diseases like autoimmune disorders and cancer by understanding how these proteins work together.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIV OF NORTH CAROLINA CHAPEL HILL (nih funded) |
| Locations | 1 site (CHAPEL HILL, UNITED STATES) |
| Trial ID | NIH-11012380 on ClinicalTrials.gov |
What this research studies
This research investigates the TAM receptors, which play a crucial role in regulating immune responses and maintaining cellular health. By exploring how these receptors interact and form complexes, the study aims to uncover new insights into their function and potential therapeutic targets for various diseases, including autoimmune disorders and cancer. The approach combines structural, biophysical, and biochemical techniques to provide a comprehensive understanding of TAM receptor activation mechanisms. Patients may benefit from this research as it could lead to the development of targeted therapies for conditions linked to TAM receptor dysregulation.
Who could benefit from this research
Good fit: Ideal candidates for this research include adults with autoimmune disorders or related conditions that may benefit from improved therapeutic strategies.
Not a fit: Patients with conditions unrelated to TAM receptor dysregulation may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new targeted therapies for autoimmune diseases and other conditions related to TAM receptor dysfunction.
How similar studies have performed: While there is growing interest in TAM receptors as therapeutic targets, this research presents a novel approach to understanding their activation mechanisms, which has not been extensively studied.
Where this research is happening
CHAPEL HILL, UNITED STATES
- UNIV OF NORTH CAROLINA CHAPEL HILL — CHAPEL HILL, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: STARBIRD, CHRYSTAL — UNIV OF NORTH CAROLINA CHAPEL HILL
- Study coordinator: STARBIRD, CHRYSTAL
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Autoimmune Diseases, autoimmune disorder, autoimmunity disease