Understanding how T regulatory cells develop and function
Official title: Translational Regulation of T Regulatory Cells
Funded at New York University School of Medicine · NIH-11032018 · Data updated 2026-11-12
This study is looking at how a special process in certain immune cells called regulatory T cells helps keep your immune system in check, which could lead to new treatments for autoimmune diseases.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University School of Medicine NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | March 1, 2024 |
| Project end | January 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $701,772 |
| NIH project number | 5R01AI137067-07 |
| Project ID | NIH-11032018 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with autoimmune conditions who may benefit from improved Treg-targeted therapies.
✕Less likely to help
Patients with non-autoimmune conditions or those not affected by immune dysregulation may not receive any benefit from this research.
What this research studies
This research investigates the mechanisms behind the development and function of regulatory T cells (Tregs), which play a crucial role in suppressing immune responses. The study focuses on a specialized translation mechanism involving a complex called DAP5/eIF3d that is unique to Tregs. By exploring how this mechanism influences Treg plasticity and stability, the research aims to uncover new insights into Treg differentiation and function. Patients may benefit from a deeper understanding of Tregs in autoimmune conditions, potentially leading to novel therapeutic strategies.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for autoimmune diseases by enhancing the understanding of Treg function.
How similar studies have gone: Other research has shown promise in understanding T cell regulation, but the specific focus on the DAP5/eIF3d mechanism is relatively novel.
Where this research is happening
-
New York University School of Medicine
New York, United States Active
Researchers
- Principal investigator: Schneider, Robert Jay — New York University School of Medicine
- Study coordinator: Schneider, Robert Jay
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.