Understanding how T cells contribute to skin fibrosis in scleroderma
Official title: Interrogation of T cell Bystander Activation in Scleroderma
Funded at Yale University · NIH-10789718 · Data updated 2026-11-12
This study is looking at how certain immune cells called CD4+ T cells contribute to skin thickening in scleroderma, with the hope of finding new ways to understand and treat the condition better for patients.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | August 1, 2024 |
| Project end | July 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $147,400 |
| NIH project number | 1R03AR083454-01 |
| Project ID | NIH-10789718 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with scleroderma or those experiencing skin fibrosis related to autoimmune diseases.
✕Less likely to help
Patients with non-autoimmune related skin conditions or those without significant skin involvement may not benefit from this research.
What this research studies
This research investigates the role of CD4+ T cells in the development of skin fibrosis associated with scleroderma, an autoimmune disease. The study focuses on how these T cells, which typically respond to specific antigens, can also be activated by inflammatory signals without direct antigen involvement. By examining the mechanisms of T cell activation and their effects on skin fibrosis, the research aims to uncover new insights into the disease process and potential therapeutic targets. Patients may benefit from a better understanding of their condition and the development of new treatment strategies.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for patients with scleroderma and related conditions, potentially reducing skin fibrosis and associated complications.
How similar studies have gone: Previous research has shown that understanding T cell functions can lead to advancements in treating autoimmune diseases, suggesting this approach has potential for success.
Where this research is happening
-
Yale University
New Haven, United States Active
Researchers
- Principal investigator: Odell, Ian D — Yale University
- Study coordinator: Odell, Ian D
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.