Understanding how T cells contribute to skin fibrosis in scleroderma
Interrogation of T cell Bystander Activation in Scleroderma
This study is looking at how certain immune cells called CD4+ T cells contribute to skin thickening in scleroderma, with the hope of finding new ways to understand and treat the condition better for patients.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-10789718 on NIH RePORTER |
What this research studies
This research investigates the role of CD4+ T cells in the development of skin fibrosis associated with scleroderma, an autoimmune disease. The study focuses on how these T cells, which typically respond to specific antigens, can also be activated by inflammatory signals without direct antigen involvement. By examining the mechanisms of T cell activation and their effects on skin fibrosis, the research aims to uncover new insights into the disease process and potential therapeutic targets. Patients may benefit from a better understanding of their condition and the development of new treatment strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with scleroderma or those experiencing skin fibrosis related to autoimmune diseases.
Not a fit: Patients with non-autoimmune related skin conditions or those without significant skin involvement may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for patients with scleroderma and related conditions, potentially reducing skin fibrosis and associated complications.
How similar studies have performed: Previous research has shown that understanding T cell functions can lead to advancements in treating autoimmune diseases, suggesting this approach has potential for success.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Odell, Ian D — Yale University
- Study coordinator: Odell, Ian D
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.