Understanding how T cells contribute to autoimmune diseases
T cells promoting transitions toward autoimmunity
This study is looking at how certain immune cells called T cells might contribute to autoimmune diseases, especially in people who are at risk for type 1 diabetes or have Down syndrome, to better understand what causes these conditions.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Benaroya Research Inst at Virginia Mason NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-10909939 on NIH RePORTER |
What this research studies
This research investigates the role of T cells in the development of autoimmune diseases, particularly focusing on individuals at risk for type 1 diabetes and those with Down syndrome. By examining how genetic, environmental, and immunological factors influence the transition from sub-clinical autoimmunity to full-blown autoimmune disease, the study aims to identify key mechanisms involved. The research utilizes advanced techniques to analyze T cell behavior and epigenetic changes in these populations, providing insights into the triggers that may lead to autoimmune conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals at risk for type 1 diabetes and those with Down syndrome.
Not a fit: Patients without a genetic predisposition to autoimmune diseases or those not at risk for type 1 diabetes or Down syndrome may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and potentially new treatments for autoimmune diseases.
How similar studies have performed: Previous research has shown promising results in understanding T cell dynamics in autoimmune diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
Seattle, United States
- Benaroya Research Inst at Virginia Mason — Seattle, United States (Active)
Researchers
- Principal investigator: Buckner, Jane Hoyt — Benaroya Research Inst at Virginia Mason
- Study coordinator: Buckner, Jane Hoyt
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.