Understanding how T cells become unresponsive to self-antigens
Altered TCR signaling in anergy
['FUNDING_R21'] · MAYO CLINIC ROCHESTER · NIH-10883780
This study is looking at how certain proteins help keep T cells from attacking the body's own tissues, which is important for preventing autoimmune diseases, and it aims to find out how these proteins work in mice to better understand how our immune system stays balanced.
Quick facts
| Phase | ['FUNDING_R21'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | MAYO CLINIC ROCHESTER (nih funded) |
| Locations | 1 site (ROCHESTER, UNITED STATES) |
| Trial ID | NIH-10883780 on ClinicalTrials.gov |
What this research studies
This research investigates the mechanisms behind T cell anergy, a state where T cells do not respond to self-antigens, which is crucial for preventing autoimmune diseases. The study focuses on the role of specific proteins and pathways, particularly the Ras/Map kinase pathway, in regulating T cell activation and anergy. By examining naturally anergic T cells in mice, the research aims to uncover how certain proteins, like Runx1, influence T cell behavior and contribute to immune tolerance. This could lead to new insights into how the immune system maintains balance and prevents autoimmunity.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with autoimmune diseases or those at risk of developing such conditions.
Not a fit: Patients with non-autoimmune conditions or those who do not have any immune system-related issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating autoimmune diseases by enhancing the body's ability to tolerate self-antigens.
How similar studies have performed: Previous research has shown promising results in understanding T cell regulation and tolerance, indicating that this approach has potential for success.
Where this research is happening
ROCHESTER, UNITED STATES
- MAYO CLINIC ROCHESTER — ROCHESTER, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SHAPIRO, VIRGINIA SMITH — MAYO CLINIC ROCHESTER
- Study coordinator: SHAPIRO, VIRGINIA SMITH
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Autoimmune Diseases