Understanding how T cells are programmed and their role in autoimmune diseases
Official title: Connecting epigenetic programming of T cells with molecular traits of the immune system in health and disease
Funded at University of Iowa · NIH-10938115 · Data updated 2026-11-12
This study is looking at how changes in certain genes in T cells might affect the immune system in both healthy people and those with autoimmune diseases, like multiple sclerosis and rheumatoid arthritis, to help find new ways to treat or prevent these conditions.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Iowa NIH-funded |
| Lab location | 1 site (Iowa City, United States) |
| Project start | August 1, 2024 |
| Project end | July 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $388,750 |
| NIH project number | 1R35GM154831-01 |
| Project ID | NIH-10938115 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with autoimmune diseases such as multiple sclerosis, rheumatoid arthritis, or type 1 diabetes.
✕Less likely to help
Patients with non-autoimmune conditions or those without any chronic diseases may not receive benefit from this research.
What this research studies
This research investigates the connection between epigenetic changes in T cells and their impact on the immune system in both healthy individuals and those with autoimmune diseases. By examining non-coding genetic variants that affect T cell function, the study aims to identify how these changes contribute to conditions like multiple sclerosis and rheumatoid arthritis. The approach involves analyzing DNA methylation patterns and regulatory elements in T cells to uncover the mechanisms behind autoimmune responses. Patients may benefit from insights that could lead to new treatments or prevention strategies for autoimmune diseases.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for patients with autoimmune diseases.
How similar studies have gone: Previous research has shown promising results in understanding the genetic and epigenetic factors involved in autoimmune diseases, indicating that this approach has potential for success.
Where this research is happening
-
University of Iowa
Iowa City, United States Active
Researchers
- Principal investigator: Issuree, Priya — University of Iowa
- Study coordinator: Issuree, Priya
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.