Understanding how T cell receptor strength affects immune regulation in autoimmune diseases
Defining how TCR strength of signal modulates Treg function
This study is looking at how certain immune cells, called T cells, work in autoimmune diseases like multiple sclerosis, to help find new ways to treat these conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Utah NIH-funded |
| Lab location | 1 site (Salt Lake City, United States) |
| Project ID | NIH-10891503 on NIH RePORTER |
What this research studies
This research investigates the role of T cell receptors (TCRs) in regulating immune responses, particularly in autoimmune diseases like multiple sclerosis. By examining how TCR strength influences the function of regulatory T cells (Tregs), the study aims to uncover the mechanisms behind Treg interactions with specific antigens. Using advanced technologies, researchers will measure the binding properties of TCRs to myelin antigens, which are crucial in autoimmune conditions. The findings could lead to new therapeutic strategies for managing autoimmune diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with autoimmune diseases such as multiple sclerosis, type I diabetes, or rheumatoid arthritis.
Not a fit: Patients with non-autoimmune conditions or those not diagnosed with the specified autoimmune diseases may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative treatments that better control autoimmune diseases and improve patient outcomes.
How similar studies have performed: Previous research has shown promising results in understanding TCR interactions in autoimmune diseases, indicating that this approach has potential for significant breakthroughs.
Where this research is happening
Salt Lake City, United States
- University of Utah — Salt Lake City, United States (Active)
Researchers
- Principal investigator: Evavold, Brian D — University of Utah
- Study coordinator: Evavold, Brian D
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.