Understanding how synaptic dysfunction contributes to mental disorders
Molecular dissection of synaptic dysfunction in mental disorders
['FUNDING_R01'] · UNIVERSITY OF MASSACHUSETTS AMHERST · NIH-10767812
This study is looking at how problems with brain connections might contribute to conditions like autism and schizophrenia, using special techniques to create brain cells from patients' own stem cells, with the hope of finding new ways to help improve mental health.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF MASSACHUSETTS AMHERST (nih funded) |
| Locations | 1 site (HADLEY, UNITED STATES) |
| Trial ID | NIH-10767812 on ClinicalTrials.gov |
What this research studies
This research investigates the role of synaptic dysfunction in mental disorders like autism and schizophrenia by using advanced genetic techniques. The team is developing a human neuronal model that incorporates patient-derived stem cells to study how specific genetic mutations affect synapse development and function. By examining the interactions between key proteins involved in synaptic signaling, the research aims to uncover the mechanisms that lead to abnormal neuronal networks associated with these disorders. This approach could provide insights into potential therapeutic targets for improving mental health outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with autism spectrum disorders or schizophrenia, particularly those with specific genetic mutations related to synaptic dysfunction.
Not a fit: Patients with mental disorders not associated with synaptic dysfunction or those without the relevant genetic mutations may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that address the underlying causes of mental disorders, improving the quality of life for affected individuals.
How similar studies have performed: Other research has shown promising results in understanding synaptic dysfunction in mental disorders, indicating that this approach has the potential for significant breakthroughs.
Where this research is happening
HADLEY, UNITED STATES
- UNIVERSITY OF MASSACHUSETTS AMHERST — HADLEY, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: PAK, CHANGHUI — UNIVERSITY OF MASSACHUSETTS AMHERST
- Study coordinator: PAK, CHANGHUI
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Affective Disorders, Mood Disorders