Understanding how stroke affects depression in older mice
Deciphering Molecular Mechanisms of Post-Stroke Depression in Aged Mice
This study is looking at how a stroke can lead to depression in older mice, focusing on how the body's immune response and inflammation play a role, and it hopes to find ways to use natural substances like oxytocin and taurine to help improve mood and recovery for people who have had a stroke.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Sci Ctr Houston NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-10945546 on NIH RePORTER |
What this research studies
This research investigates the biological mechanisms that lead to post-stroke depression (PSD) in older mice. By studying the effects of ischemic stroke, the researchers aim to understand how factors like immune response and inflammation contribute to depression in stroke survivors. The study will explore the role of oxytocin and taurine, a naturally occurring amino acid, in regulating mood and reducing inflammation, which could provide insights into potential treatments for humans. The findings may help improve recovery and quality of life for stroke survivors.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults who have experienced a stroke and are showing signs of depression.
Not a fit: Patients who have not had a stroke or are under 21 years old may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that alleviate depression in stroke survivors, enhancing their recovery and overall well-being.
How similar studies have performed: Previous research has indicated that targeting neuroinflammation and neurotransmitter regulation can improve outcomes in similar conditions, suggesting potential for success in this approach.
Where this research is happening
Houston, United States
- University of Texas Hlth Sci Ctr Houston — Houston, United States (Active)
Researchers
- Principal investigator: Venna, Venugopal Reddy — University of Texas Hlth Sci Ctr Houston
- Study coordinator: Venna, Venugopal Reddy
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.