Understanding how stress coping mechanisms work in the brain
Official title: Neural circuits and mechanisms underlying active and passive stress coping
Funded at University of Iowa · NIH-11008917 · Data updated 2026-11-12
This study is looking at how different parts of the brain help animals handle stress, which could help us understand stress-related issues in people and lead to better treatments.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Iowa NIH-funded |
| Lab location | 1 site (Iowa City, United States) |
| Project start | February 15, 2023 |
| Project end | December 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $553,333 |
| NIH project number | 5R01MH132207-03 |
| Project ID | NIH-11008917 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals experiencing chronic stress or stress-related disorders.
✕Less likely to help
Patients who do not experience stress-related issues or have acute stress responses may not benefit from this research.
What this research studies
This research investigates how different brain circuits influence the way animals cope with stress, focusing on both active and passive coping strategies. By using advanced techniques like optogenetics, researchers will analyze how specific pathways in the brain affect behavior in response to stress. The study aims to identify the changes in brain activity that occur when animals are subjected to chronic stress, which may lead to a better understanding of stress-related disorders in humans. Ultimately, this research seeks to uncover the biological mechanisms that underlie coping behaviors, which could inform future treatments for stress-related conditions.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for managing stress and preventing stress-related disorders in patients.
How similar studies have gone: Previous research has shown promising results in understanding stress coping mechanisms, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Iowa
Iowa City, United States Active
Researchers
- Principal investigator: Radley, Jason J — University of Iowa
- Study coordinator: Radley, Jason J
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.