Understanding how stress affects mental health through genetic changes in mice
Epigenetic insights into stress vulnerability in mouse models
This study is looking at how certain genes might make some people more sensitive to stress and related mental health issues, using specially modified mice to see how stress affects their brains and behavior, which could help us find better ways to diagnose and treat these conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-11025201 on NIH RePORTER |
What this research studies
This research investigates the genetic and molecular mechanisms that make some individuals more vulnerable to stress-related psychiatric disorders. Using genetically modified mouse models, the team will explore how chronic stress impacts brain function and behavior, focusing on a specific transcription factor called Yin Yang 1 (YY1). By employing advanced genomic technologies, the study aims to uncover the biological pathways that link stress to mental health issues, potentially leading to new diagnostic and treatment strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research would be individuals with a history of stress-related mental health issues or those interested in the genetic factors influencing such conditions.
Not a fit: Patients who do not have a history of stress-related psychiatric disorders or are not affected by chronic stress may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for stress-related psychiatric disorders.
How similar studies have performed: Previous research has shown promising results in understanding the genetic basis of stress vulnerability, indicating that this approach could yield valuable insights.
Where this research is happening
Philadelphia, United States
- University of Pennsylvania — Philadelphia, United States (Active)
Researchers
- Principal investigator: Zhou, Zhaolan — University of Pennsylvania
- Study coordinator: Zhou, Zhaolan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.