Understanding how stress affects impulsivity and addiction in the brain.
Cell-specific epigenetic and transcriptomic signatures of impulsivity and its regulation by stress in the nucleus accumbens
['FUNDING_R21'] · TEMPLE UNIV OF THE COMMONWEALTH · NIH-10848182
This study looks at how stress and tough experiences early in life can affect the brain and lead to impulsive behaviors and substance use problems, using rodent models to find clues that might help us understand who is more likely to struggle with addiction, so we can create better prevention and treatment options for those at risk.
Quick facts
| Phase | ['FUNDING_R21'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | TEMPLE UNIV OF THE COMMONWEALTH (nih funded) |
| Locations | 1 site (PHILADELPHIA, UNITED STATES) |
| Trial ID | NIH-10848182 on ClinicalTrials.gov |
What this research studies
This research investigates the biological factors that contribute to impulsivity and the development of substance use disorders, particularly in the context of stress. By using rodent models, the study examines how early life adversity influences gene expression and chromatin changes in specific brain cells, particularly in the nucleus accumbens, which is crucial for addiction-related behaviors. The goal is to identify molecular signatures that predict resilience to substance abuse, which could lead to improved prevention strategies and tailored pain management approaches for individuals at risk.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a history of early life stress or those at risk for developing substance use disorders.
Not a fit: Patients who do not have a history of substance use or those not affected by early life stress may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective prevention strategies for opioid use disorder and improved pain management techniques.
How similar studies have performed: Previous research has shown promising results in understanding the biological underpinnings of addiction and impulsivity, suggesting that this approach could yield valuable insights.
Where this research is happening
PHILADELPHIA, UNITED STATES
- TEMPLE UNIV OF THE COMMONWEALTH — PHILADELPHIA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: WIMMER, MATHIEU — TEMPLE UNIV OF THE COMMONWEALTH
- Study coordinator: WIMMER, MATHIEU
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Mental health disorders, Psychiatric Disease, Psychiatric Disorder, psychological disorder, Mental disorders