Understanding how stress affects brain function and behavior
Defining neuron- and microglia-specific contributions to prefrontal cortex dysfunction in chronic stress
This study is looking at how long-term stress affects the brain, especially a part called the prefrontal cortex that helps with thinking and behavior, to better understand how it might relate to conditions like depression.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Cincinnati NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project ID | NIH-10788412 on NIH RePORTER |
What this research studies
This research investigates the effects of chronic stress on the brain, particularly focusing on the prefrontal cortex, which is crucial for behavior and cognition. By using preclinical models that simulate chronic stress, the study aims to uncover how interactions between neurons and microglia (a type of brain cell) contribute to changes in brain function and behavior. The research will explore the role of specific signaling pathways and stress hormones in these processes, which could lead to new insights into psychiatric disorders like major depressive disorder.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals experiencing symptoms of psychiatric disorders, particularly those related to chronic stress and major depressive disorder.
Not a fit: Patients with acute stress responses or those not experiencing psychiatric symptoms may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for patients suffering from psychiatric disorders related to chronic stress.
How similar studies have performed: Previous research has shown promising results in understanding the role of microglia in brain function and psychiatric disorders, indicating that this approach has potential for significant findings.
Where this research is happening
Cincinnati, United States
- University of Cincinnati — Cincinnati, United States (Active)
Researchers
- Principal investigator: Wohleb, Eric S — University of Cincinnati
- Study coordinator: Wohleb, Eric S
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.