Understanding how STING signaling affects immune responses in health and disease
STING Signaling in Health and Disease
This study is looking at how a specific part of the immune system, called the cGAS-STING pathway, affects the way T cells develop and work, especially in fighting cancer, using specially designed mice to learn more about it.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project ID | NIH-11125035 on NIH RePORTER |
What this research studies
This research investigates the cGAS-STING signaling pathway, which plays a vital role in the innate immune system. The study focuses on how STING expression and signaling in T cells can influence their development and function, particularly in the context of cancer. By using specially engineered mice, the researchers aim to uncover the regulatory mechanisms of STING and its impact on T cell immunity. This could lead to new insights into how the immune system can be harnessed for cancer treatment.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with cancers or autoimmune diseases that may benefit from enhanced immune responses.
Not a fit: Patients with conditions unrelated to immune system function or those not currently undergoing treatment for cancer or autoimmune diseases may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved cancer immunotherapies by enhancing T cell responses.
How similar studies have performed: Previous research has shown promising results in manipulating STING signaling for cancer treatment, indicating potential success for this approach.
Where this research is happening
Dallas, United States
- Ut Southwestern Medical Center — Dallas, United States (Active)
Researchers
- Principal investigator: Yan, Nan — Ut Southwestern Medical Center
- Study coordinator: Yan, Nan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.