Understanding how Staphylococcus aureus resists beta-lactam antibiotics
The mechanism of the beta-lactam resistance in Staphylococcus aureus
This study is looking into how certain strains of Staphylococcus aureus, especially the ones that are resistant to common antibiotics, manage to resist treatment, and it hopes to find new ways to help patients by understanding the role of specific enzymes in this process.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Indiana University Indianapolis NIH-funded |
| Lab location | 1 site (Indianapolis, United States) |
| Project ID | NIH-10674849 on NIH RePORTER |
What this research studies
This research investigates the mechanisms behind the resistance of Staphylococcus aureus, particularly methicillin-resistant strains (MRSA), to beta-lactam antibiotics, which are commonly used to treat bacterial infections. The study focuses on specific enzymes produced by MRSA that contribute to this resistance, including PBP2A and FtsH. By examining how these enzymes interact with the antibiotics and affect bacterial cell wall synthesis, the research aims to identify potential strategies to overcome this resistance. Patients may benefit from new treatment options that could be developed based on these findings.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients suffering from infections caused by methicillin-resistant Staphylococcus aureus (MRSA).
Not a fit: Patients with infections caused by bacteria other than Staphylococcus aureus may not receive benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for MRSA infections, improving patient outcomes.
How similar studies have performed: Previous research has shown promising results in understanding antibiotic resistance mechanisms, suggesting that this approach may lead to significant advancements.
Where this research is happening
Indianapolis, United States
- Indiana University Indianapolis — Indianapolis, United States (Active)
Researchers
- Principal investigator: Bae, Taeok — Indiana University Indianapolis
- Study coordinator: Bae, Taeok
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.