Understanding how specific proteins in the brain help with nerve growth and development
Official title: Uncovering the Molecular Function of the Tweety Homologue Membrane Protein Family
Funded at Cornell University · NIH-11126198 · Data updated 2026-11-12
This study is looking at special proteins that help our brains grow and heal, and it aims to understand how they work together, which could lead to new ways to treat brain and nerve problems.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cornell University NIH-funded |
| Lab location | 1 site (Ithaca, United States) |
| Project start | March 1, 2025 |
| Project end | February 28, 2027 |
| Funding year | 2025 |
| Award (this year) | $227,035 |
| NIH project number | 1R21NS142832-01 |
| Project ID | NIH-11126198 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with neurological disorders or conditions affecting nerve growth and development.
✕Less likely to help
Patients with non-neurological conditions or those whose issues are unrelated to nerve growth may not benefit from this research.
What this research studies
This research investigates the Tweety Homologue membrane protein family, which is crucial for brain development and nerve regeneration. By using advanced techniques like cryogenic electron microscopy, the researchers aim to uncover how these proteins function and interact with other proteins in the nervous system. The study focuses on understanding the mechanisms behind neurogenesis and how these proteins can influence nerve growth and signaling. This knowledge could lead to new treatments for neurological diseases.
Why it matters
Potential benefit: If successful, this research could lead to innovative therapies for various neurological conditions by targeting the mechanisms of nerve growth and regeneration.
How similar studies have gone: Previous research has shown promising results in understanding similar membrane proteins and their roles in neurological functions, suggesting potential for success in this area.
Where this research is happening
-
Cornell University
Ithaca, United States Active
Researchers
- Principal investigator: Kawate, Toshimitsu — Cornell University
- Study coordinator: Kawate, Toshimitsu
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.