Understanding how specific proteins affect enamel formation
Official title: Ameloblast-specific mineral ribbon attachment/elongation complex in enamel formation
Funded at University of Michigan at Ann Arbor · NIH-11017291 · Data updated 2026-11-12
This study is looking at how specific proteins help create dental enamel and how problems with these proteins can lead to conditions like amelogenesis imperfecta, so it could help people with enamel issues understand their condition better.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project start | July 1, 2024 |
| Project end | June 30, 2027 |
| Funding year | 2024 |
| Award (this year) | $249,000 |
| NIH project number | 4R00DE030858-03 |
| Project ID | NIH-11017291 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research include individuals with amelogenesis imperfecta or other enamel formation disorders.
✕Less likely to help
Patients without enamel formation disorders or those not affected by genetic factors related to amelogenesis may not receive benefit from this research.
What this research studies
This research investigates the role of certain proteins in the formation of dental enamel, particularly focusing on how defects in these proteins can lead to conditions like amelogenesis imperfecta. The study will utilize mouse models to identify and analyze the components involved in the mineral ribbon attachment complex that is crucial for enamel development. By examining the molecular interactions and structural changes during enamel formation, the research aims to provide insights into the underlying mechanisms of enamel defects. Patients with enamel-related conditions may benefit from the findings of this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and potential treatments for enamel defects, benefiting patients with conditions like amelogenesis imperfecta.
How similar studies have gone: Previous research has shown success in understanding enamel formation and defects through similar genetic and molecular approaches, indicating a promising avenue for this study.
Where this research is happening
-
University of Michigan at Ann Arbor
Ann Arbor, United States Active
Researchers
- Principal investigator: Liang, Tian — University of Michigan at Ann Arbor
- Study coordinator: Liang, Tian
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.