Understanding how specific proteins affect cell survival and function
Official title: Probing the Role of Insulin-Like Growth Factor-Binding Protein 3 and Humanin in Regulating Hyaluronan Function
Funded at Eastern Michigan University · NIH-10439105 · Data updated 2026-11-12
This study is looking at how a protein called IGFBP-3 works with certain molecules in our body to help cells communicate and stay healthy, with the goal of finding new ways to treat diseases caused by cell problems.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Eastern Michigan University NIH-funded |
| Lab location | 1 site (Ypsilanti, United States) |
| Project start | September 1, 2019 |
| Project end | August 31, 2025 |
| Funding year | 2022 |
| Award (this year) | $445,500 |
| NIH project number | 2R15GM131222-02 |
| Project ID | NIH-10439105 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research would include individuals with conditions related to cell survival and dysfunction, such as certain cancers or degenerative diseases.
✕Less likely to help
Patients with conditions unrelated to cellular signaling or those who do not have issues with cell survival may not benefit from this research.
What this research studies
This research investigates the role of insulin-like growth factor-binding protein 3 (IGFBP-3) in regulating the function of glycosaminoglycans (GAGs), which are important components of the extracellular matrix. The study aims to uncover how IGFBP-3 interacts with these molecules to influence cell signaling and survival. By exploring these interactions, the researchers hope to develop methods to control these protein-GAG interactions, potentially leading to new therapeutic strategies for diseases linked to cell dysfunction.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance cell survival and function in various diseases.
How similar studies have gone: While the specific approach of manipulating protein-GAG interactions is novel, similar research has shown promise in understanding cellular processes and developing targeted therapies.
Where this research is happening
-
Eastern Michigan University
Ypsilanti, United States Active
Researchers
- Principal investigator: Guy Evans, Hedeel I. — Eastern Michigan University
- Study coordinator: Guy Evans, Hedeel I.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.