Understanding How Specific Immune Switches Cause Inflammation
NLRP1 and CARD8 Inflammasomes: Assembly, Regulation and Stress Sensing
['FUNDING_R01'] · BOSTON CHILDREN'S HOSPITAL · NIH-11099751
This research explores how specific immune system switches, called inflammasomes, are put together and controlled, which helps us understand their role in inflammation and autoimmune diseases.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BOSTON CHILDREN'S HOSPITAL (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-11099751 on ClinicalTrials.gov |
What this research studies
This research aims to understand the detailed workings of two important immune system components, NLRP1 and CARD8 inflammasomes. These inflammasomes act like switches that can trigger inflammation and a specific type of cell death. By learning how these switches are assembled and regulated, we hope to uncover new ways to control unwanted inflammation. This knowledge could be especially helpful for people living with autoimmune diseases, where the immune system mistakenly attacks the body. We are looking closely at the unique parts of these inflammasomes to see how they sense stress and activate their inflammatory responses.
Who could benefit from this research
Good fit: This foundational research is not directly recruiting patients but aims to benefit individuals with autoimmune diseases or other conditions involving uncontrolled inflammation.
Not a fit: Patients seeking immediate treatment or direct clinical intervention would not find direct benefit from this basic science research.
Why it matters
Potential benefit: If successful, this work could lead to new ways to control inflammation and cell death, potentially offering new treatments for autoimmune diseases and other inflammatory conditions.
How similar studies have performed: While the general concept of inflammasomes is established, this specific focus on the detailed assembly and regulation of NLRP1 and CARD8, particularly their unique FIIND domains, represents a novel and less explored area.
Where this research is happening
BOSTON, UNITED STATES
- BOSTON CHILDREN'S HOSPITAL — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: WU, HAO — BOSTON CHILDREN'S HOSPITAL
- Study coordinator: WU, HAO
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Autoimmune Diseases