Understanding how specific immune cells interact with gut bacteria
Building tools to study commensal-specific CD8+ T cells in the small intestine
['FUNDING_R03'] · BENAROYA RESEARCH INST AT VIRGINIA MASON · NIH-11118533
This study is looking at how certain immune cells in the small intestine work with good bacteria to keep our gut healthy, and it could help us understand how to prevent gut-related diseases.
Quick facts
| Phase | ['FUNDING_R03'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BENAROYA RESEARCH INST AT VIRGINIA MASON (nih funded) |
| Locations | 1 site (SEATTLE, UNITED STATES) |
| Trial ID | NIH-11118533 on ClinicalTrials.gov |
What this research studies
This research investigates the role of commensal-specific CD8+ T cells in the small intestine, focusing on how these immune cells interact with beneficial gut bacteria. By developing new mouse models, the research aims to uncover the mechanisms that regulate these immune responses and their impact on gut health. The findings could provide insights into how these immune cells help maintain a healthy balance of gut microbiota and prevent diseases related to gut inflammation.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include individuals with autoimmune conditions or inflammatory bowel diseases.
Not a fit: Patients with non-autoimmune gastrointestinal disorders may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies for conditions like inflammatory bowel disease by enhancing our understanding of gut immunity.
How similar studies have performed: Other research has shown promising results in understanding immune responses to gut microbiota, suggesting that this approach could yield valuable insights.
Where this research is happening
SEATTLE, UNITED STATES
- BENAROYA RESEARCH INST AT VIRGINIA MASON — SEATTLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: HARRISON, OLIVER JAMES — BENAROYA RESEARCH INST AT VIRGINIA MASON
- Study coordinator: HARRISON, OLIVER JAMES
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Autoimmune Diseases, autoimmune disorder