Understanding how specific immune cells interact with gut bacteria
Investigating a RORgt-expressing antigen presenting cell required for peripheral Treg responses to gut microbiota
['FUNDING_FELLOWSHIP'] · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · NIH-10997014
This study is looking at a special kind of immune cell in the gut that helps keep things balanced between fighting off germs and preventing inflammation, which could lead to better treatments for people with inflammatory bowel diseases (IBD).
Quick facts
| Phase | ['FUNDING_FELLOWSHIP'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | NEW YORK UNIVERSITY SCHOOL OF MEDICINE (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-10997014 on ClinicalTrials.gov |
What this research studies
This research investigates a unique type of immune cell in the gut that expresses a protein called RORgt, which plays a crucial role in how our immune system responds to the bacteria living in our intestines. By studying these RORgt-expressing antigen presenting cells (APCs), the research aims to uncover how they help maintain a balance between tolerance and inflammation in the gut. This could lead to new strategies for treating inflammatory bowel diseases (IBD) by enhancing our understanding of how these immune cells function and interact with gut microbiota.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with inflammatory bowel diseases or those experiencing gut-related immune issues.
Not a fit: Patients with non-gut related autoimmune diseases or those without any gastrointestinal symptoms may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for inflammatory bowel diseases, improving the quality of life for patients suffering from these conditions.
How similar studies have performed: Previous research has shown promise in understanding immune responses to gut microbiota, but the specific role of RORgt-expressing APCs is still being explored, making this a novel investigation.
Where this research is happening
NEW YORK, UNITED STATES
- NEW YORK UNIVERSITY SCHOOL OF MEDICINE — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CHEN, FRANCIS M — NEW YORK UNIVERSITY SCHOOL OF MEDICINE
- Study coordinator: CHEN, FRANCIS M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Autoimmune Diseases